Two sample MR report

Telomere_length against aparc-DKTatlas rh area medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0320338	0.1210578	0.7938856
Weighted median	23	-0.0676667	0.0617292	0.2729977
Inverse variance weighted	23	-0.0533006	0.0468597	0.2553505
Simple mode	23	-0.0932540	0.1139969	0.4221068
Weighted mode	23	-0.0660904	0.0747616	0.3862474

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.14511	21	0.0712766
Inverse variance weighted	32.01487	22	0.0771429

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052395	0.0068419	0.4523191

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010272	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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