Two sample MR report

Telomere_length against aparc-DKTatlas rh area lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0817060	0.1141947	0.4821822
Weighted median	23	0.0669772	0.0604915	0.2682008
Inverse variance weighted	23	-0.0012685	0.0442025	0.9771065
Simple mode	23	0.1032284	0.1341295	0.4497118
Weighted mode	23	0.1298594	0.0890695	0.1589813

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.71436	21	0.1484398
Inverse variance weighted	28.48718	22	0.1600923

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049389	0.0064541	0.4526455

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008633	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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