Two sample MR report

Telomere_length against aparc-DKTatlas rh area lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0632245	0.1282820	0.6272287
Weighted median	23	0.0016543	0.0653229	0.9797963
Inverse variance weighted	23	-0.0400803	0.0498614	0.4214931
Simple mode	23	-0.0762205	0.1164308	0.5194843
Weighted mode	23	0.0236019	0.0805003	0.7721241

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.97330	21	0.0284262
Inverse variance weighted	36.24795	22	0.0285589

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063429	0.0072502	0.3915476

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011306	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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