Two sample MR report

Telomere_length against aparc-DKTatlas rh area lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0323840	0.1207285	0.7911330
Weighted median	23	0.0286319	0.0572658	0.6170866
Inverse variance weighted	23	0.0203213	0.0463388	0.6609973
Simple mode	23	-0.0381545	0.0950543	0.6920004
Weighted mode	23	0.0148302	0.0673955	0.8278630

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.97518	21	0.0740720
Inverse variance weighted	31.30696	22	0.0900033

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032361	0.0068233	0.640201

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009569	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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