Two sample MR report

Telomere_length against aparc-DKTatlas rh area isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0555533	0.1326441	0.6796043
Weighted median	23	0.0320111	0.0565704	0.5714873
Inverse variance weighted	23	0.0074944	0.0509624	0.8830862
Simple mode	23	0.0141416	0.0929663	0.8804820
Weighted mode	23	0.0398495	0.0632551	0.5351957

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.39112	21	0.0151743
Inverse variance weighted	37.86588	22	0.0189668

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038711	0.0074968	0.6109891

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011485	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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