Two sample MR report

Telomere_length against aparc-DKTatlas rh area insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0936000	0.1529694	0.5471808
Weighted median	23	-0.0266374	0.0564478	0.6370022
Inverse variance weighted	23	0.0106128	0.0591586	0.8576266
Simple mode	23	0.1168504	0.1074843	0.2887433
Weighted mode	23	-0.0278902	0.0600541	0.6469123

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.72942	21	0.0003978
Inverse variance weighted	51.02658	22	0.0004253

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063986	0.0086454	0.4674251

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015483	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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