Two sample MR report

Telomere_length against aparc-DKTatlas rh area inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0051444	0.0994054	0.9592155
Weighted median	23	-0.0461859	0.0578398	0.4245722
Inverse variance weighted	23	-0.0154438	0.0388454	0.6909463
Simple mode	23	-0.0278505	0.0936735	0.7690154
Weighted mode	23	-0.0508598	0.0709560	0.4810506

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.59590	21	0.4838473
Inverse variance weighted	20.64653	22	0.5426653

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012641	0.0056182	0.8241505

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006304	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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