Two sample MR report

Telomere_length against aparc-DKTatlas rh area inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0462069	0.1253507	0.7161004
Weighted median	23	-0.0312496	0.0564638	0.5799585
Inverse variance weighted	23	-0.0300415	0.0483524	0.5343998
Simple mode	23	0.0473100	0.1011488	0.6445803
Weighted mode	23	-0.0039824	0.0638369	0.9508200

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.39217	21	0.0420454
Inverse variance weighted	34.08656	22	0.0481377

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046816	0.0070845	0.5159094

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001051	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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