Two sample MR report

Telomere_length against aparc-DKTatlas rh area fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1717895	0.0994056	0.0986360
Weighted median	23	-0.0043042	0.0569640	0.9397698
Inverse variance weighted	23	0.0118489	0.0390504	0.7615656
Simple mode	23	0.0126251	0.1077292	0.9077703
Weighted mode	23	0.0224806	0.0800573	0.7814823

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.17755	21	0.5737515
Inverse variance weighted	22.23291	22	0.4460626

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0098204	0.0056182	0.0950783

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006766	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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