Two sample MR report

Telomere_length against aparc-DKTatlas rh area entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0123448	0.1033270	0.9060360
Weighted median	23	-0.0081019	0.0558744	0.8847091
Inverse variance weighted	23	-0.0218476	0.0395705	0.5808675
Simple mode	23	0.0578373	0.1081806	0.5982635
Weighted mode	23	-0.0756290	0.0823540	0.3683999

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.68939	21	0.3607604
Inverse variance weighted	22.82903	22	0.4114372

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020994	0.0058398	0.7228114

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007013	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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