Two sample MR report

Telomere_length against aparc-DKTatlas rh area cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0356785	0.1243054	0.7769080
Weighted median	23	0.0910730	0.0640877	0.1552972
Inverse variance weighted	23	-0.0061918	0.0476100	0.8965241
Simple mode	23	-0.1256906	0.1352259	0.3627244
Weighted mode	23	0.1338453	0.0946382	0.1712753

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.83982	21	0.0480237
Inverse variance weighted	33.04922	22	0.0611848

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025709	0.0070255	0.7180769

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010022	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8