Two sample MR report

Telomere_length against aparc-DKTatlas rh area caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1535968	0.1091977	0.1741747
Weighted median	23	-0.0895505	0.0561859	0.1109755
Inverse variance weighted	23	-0.0656370	0.0424438	0.1219974
Simple mode	23	-0.0671073	0.0977172	0.4994157
Weighted mode	23	-0.0739134	0.0688451	0.2946294

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.34110	21	0.2326933
Inverse variance weighted	26.26518	22	0.2404707

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054007	0.0061716	0.3914237

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008824	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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