Two sample MR report

Telomere_length against aparc-DKTatlas rh area caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0110854	0.1020915	0.9145638
Weighted median	23	-0.0583072	0.0560623	0.2983198
Inverse variance weighted	23	-0.0260259	0.0391222	0.5058927
Simple mode	23	-0.0105552	0.0899301	0.9076308
Weighted mode	23	-0.0540391	0.0719604	0.4606371

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.14930	21	0.3909504
Inverse variance weighted	22.31379	22	0.4412980

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022786	0.00577	0.6968903

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006897	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8