Two sample MR report

Telomere_length against aparc-DKTatlas lh volume transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2454288	0.1064981	0.0315014
Weighted median	23	-0.1288001	0.0568047	0.0233645
Inverse variance weighted	23	-0.1056483	0.0425830	0.0131015
Simple mode	23	-0.1835420	0.0901695	0.0540189
Weighted mode	23	-0.1616218	0.0605649	0.0140324

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.10431	21	0.2880317
Inverse variance weighted	26.43805	22	0.2333504

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085825	0.0060191	0.1685951

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010253	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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