Two sample MR report

Telomere_length against aparc-DKTatlas lh volume supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0606985	0.0994052	0.5480058
Weighted median	23	-0.1061563	0.0535286	0.0473483
Inverse variance weighted	23	-0.1158533	0.0388450	0.0028595
Simple mode	23	-0.0730707	0.0866246	0.4080091
Weighted mode	23	-0.0975164	0.0620968	0.1305961

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.57603	21	0.7364637
Inverse variance weighted	16.93937	22	0.7666992

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033865	0.0056182	0.5531114

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007828	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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