Two sample MR report

Telomere_length against aparc-DKTatlas lh volume superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0657263	0.0997677	0.5171872
Weighted median	23	-0.0944618	0.0532028	0.0758145
Inverse variance weighted	23	-0.0857569	0.0388453	0.0272686
Simple mode	23	-0.0960735	0.0891551	0.2928868
Weighted mode	23	-0.0930011	0.0582683	0.1247360

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.15320	21	0.4496227
Inverse variance weighted	21.20112	22	0.5083397

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012299	0.0056386	0.829445

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007901	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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