Two sample MR report

Telomere_length against aparc-DKTatlas lh volume superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1205777	0.0994047	0.2385994
Weighted median	23	-0.0772163	0.0587417	0.1886757
Inverse variance weighted	23	-0.0543184	0.0388450	0.1620119
Simple mode	23	-0.0166012	0.1146270	0.8861651
Weighted mode	23	-0.1509185	0.0869457	0.0965899

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.24074	21	0.5060619
Inverse variance weighted	20.76512	22	0.5352923

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040684	0.0056182	0.47697

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006885	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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