Two sample MR report

Telomere_length against aparc-DKTatlas lh volume superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1578562	0.1200887	0.2028555
Weighted median	23	-0.1735080	0.0610387	0.0044749
Inverse variance weighted	23	-0.1034269	0.0461126	0.0249019
Simple mode	23	-0.1832080	0.1029388	0.0889317
Weighted mode	23	-0.1962031	0.0789041	0.0209712

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.64925	21	0.0796968
Inverse variance weighted	31.00311	22	0.0960520

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003342	0.0067872	0.6275485

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011542	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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