Two sample MR report

Telomere_length against aparc-DKTatlas lh volume rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0940094	0.1132414	0.4157823
Weighted median	23	-0.1678953	0.0652794	0.0101128
Inverse variance weighted	23	-0.1108497	0.0432619	0.0103983
Simple mode	23	-0.2149569	0.1350127	0.1256248
Weighted mode	23	-0.2180312	0.0902643	0.0244671

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.25458	21	0.1625846
Inverse variance weighted	27.28845	22	0.2004749

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001034	0.0064002	0.873198

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010736	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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