Two sample MR report

Telomere_length against aparc-DKTatlas lh volume rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0869282	0.1327200	0.5195948
Weighted median	23	-0.0150789	0.0610957	0.8050573
Inverse variance weighted	23	-0.0891302	0.0506724	0.0785861
Simple mode	23	0.0612850	0.1166335	0.6045269
Weighted mode	23	0.0125522	0.0949342	0.8960125

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.43818	21	0.0149851
Inverse variance weighted	37.43876	22	0.0211618

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001352	0.0075012	0.9857894

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012938	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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