Two sample MR report

Telomere_length against aparc-DKTatlas lh volume precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2823874	0.1273765	0.0377965
Weighted median	23	-0.1018933	0.0617439	0.0988904
Inverse variance weighted	23	-0.0412033	0.0533058	0.4395461
Simple mode	23	-0.1347348	0.0971163	0.1792284
Weighted mode	23	-0.1452711	0.0725559	0.0577426

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.48132	21	0.0321623
Inverse variance weighted	41.42914	22	0.0073236

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0148087	0.007199	0.0523158

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012895	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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