Two sample MR report

Telomere_length against aparc-DKTatlas lh volume precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2568327	0.1122933	0.0326681
Weighted median	23	-0.1658642	0.0596826	0.0054509
Inverse variance weighted	23	-0.1208396	0.0446048	0.0067463
Simple mode	23	-0.2308750	0.1064247	0.0411331
Weighted mode	23	-0.1952778	0.0712388	0.0119216

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.79959	21	0.1775855
Inverse variance weighted	29.00863	22	0.1446147

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00835	0.0063466	0.2024686

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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