Two sample MR report

Telomere_length against aparc-DKTatlas lh volume posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1391895	0.1222210	0.2675973
Weighted median	23	-0.1192638	0.0581240	0.0401808
Inverse variance weighted	23	-0.0597226	0.0472142	0.2058964
Simple mode	23	-0.1472078	0.0888527	0.1117619
Weighted mode	23	-0.1507530	0.0678468	0.0368824

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.74525	21	0.0621181
Inverse variance weighted	32.49949	22	0.0692701

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048793	0.0069077	0.4877304

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010564	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8