Two sample MR report

Telomere_length against aparc-DKTatlas lh volume postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2699080	0.1088650	0.0217276
Weighted median	23	-0.1458854	0.0579123	0.0117663
Inverse variance weighted	23	-0.0951752	0.0444709	0.0323410
Simple mode	23	-0.0678540	0.1177166	0.5701836
Weighted mode	23	-0.1825622	0.0821505	0.0368573

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.18799	21	0.2391139
Inverse variance weighted	28.83479	22	0.1496383

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0107286	0.0061528	0.0958364

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010556	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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