Two sample MR report

Telomere_length against aparc-DKTatlas lh volume pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1469797	0.1286439	0.2660927
Weighted median	23	-0.0588062	0.0611704	0.3363758
Inverse variance weighted	23	-0.0253746	0.0503336	0.6141710
Simple mode	23	-0.1807149	0.1179588	0.1397730
Weighted mode	23	-0.1563025	0.0944117	0.1120113

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.17168	21	0.0270341
Inverse variance weighted	36.93799	22	0.0240292

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074665	0.0072706	0.316132

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011322	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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