Two sample MR report

Telomere_length against aparc-DKTatlas lh volume parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1276837	0.0994059	0.2129678
Weighted median	23	-0.0459472	0.0576585	0.4255180
Inverse variance weighted	23	-0.0302704	0.0388454	0.4358302
Simple mode	23	0.0248521	0.0968927	0.7999555
Weighted mode	23	-0.0393334	0.0752615	0.6064602

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.79156	21	0.6621537
Inverse variance weighted	18.92495	22	0.6499582

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059812	0.0056182	0.2991431

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005919	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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