Two sample MR report

Telomere_length against aparc-DKTatlas lh volume parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1230957	0.1204543	0.3184437
Weighted median	23	-0.0260710	0.0550570	0.6358368
Inverse variance weighted	23	0.0084451	0.0475046	0.8588994
Simple mode	23	0.0234866	0.0986618	0.8140444
Weighted mode	23	-0.0207319	0.0635613	0.7473763

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.83375	21	0.0764697
Inverse variance weighted	32.90031	22	0.0632899

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080766	0.0068078	0.2487241

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009983	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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