Two sample MR report

Telomere_length against aparc-DKTatlas lh volume parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2672376	0.0994041	0.0137591
Weighted median	23	-0.0879588	0.0566652	0.1206019
Inverse variance weighted	23	-0.0570925	0.0388448	0.1416270
Simple mode	23	-0.0796720	0.1108291	0.4797857
Weighted mode	23	-0.1540104	0.0829171	0.0766916

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.46362	21	0.7430625
Inverse variance weighted	21.73830	22	0.4755987

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0129031	0.0056182	0.032025

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007242	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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