Two sample MR report

Telomere_length against aparc-DKTatlas lh volume parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1404933	0.0994056	0.1722101
Weighted median	23	-0.0704965	0.0521710	0.1766130
Inverse variance weighted	23	-0.0571731	0.0388453	0.1410707
Simple mode	23	-0.0430432	0.0872268	0.6265758
Weighted mode	23	-0.0849576	0.0561060	0.1442023

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.20528	21	0.8125121
Inverse variance weighted	16.03445	22	0.8141722

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051158	0.0056182	0.3728468

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005515	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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