Two sample MR report

Telomere_length against aparc-DKTatlas lh volume paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2294656	0.1302222	0.0926025
Weighted median	23	-0.1466173	0.0645721	0.0231714
Inverse variance weighted	23	-0.0513654	0.0522660	0.3257214
Simple mode	23	-0.2000480	0.1546245	0.2091648
Weighted mode	23	-0.2262466	0.0807903	0.0104256

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.04157	21	0.0216313
Inverse variance weighted	39.83044	22	0.0113154

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0109355	0.00736	0.1521887

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012599	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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