Two sample MR report

Telomere_length against aparc-DKTatlas lh volume middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1306028	0.1021548	0.2150304
Weighted median	23	0.0147924	0.0558353	0.7910644
Inverse variance weighted	23	0.0252203	0.0414737	0.5431181
Simple mode	23	0.0263788	0.1139633	0.8190912
Weighted mode	23	-0.0336568	0.0755655	0.6603837

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.17807	21	0.3893112
Inverse variance weighted	25.07820	22	0.2933498

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095675	0.0057736	0.1123593

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007727	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8