Two sample MR report

Telomere_length against aparc-DKTatlas lh volume medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0252186	0.1425471	0.8612708
Weighted median	23	-0.0202588	0.0618537	0.7432688
Inverse variance weighted	23	-0.0069254	0.0544479	0.8987873
Simple mode	23	-0.0488821	0.1108058	0.6634086
Weighted mode	23	-0.0042604	0.0658326	0.9489843

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.18278	21	0.0029789
Inverse variance weighted	43.22275	22	0.0044299

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011232	0.0080564	0.8904496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013107	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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