Two sample MR report

Telomere_length against aparc-DKTatlas lh volume lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1155937	0.0994061	0.2579376
Weighted median	23	0.0109507	0.0577675	0.8496498
Inverse variance weighted	23	-0.0194140	0.0388454	0.6172319
Simple mode	23	0.0100445	0.0991416	0.9202182
Weighted mode	23	0.0291422	0.0702633	0.6823365

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.80341	21	0.6614089
Inverse variance weighted	18.90826	22	0.6509862

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059054	0.0056182	0.3051489

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005806	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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