Two sample MR report

Telomere_length against aparc-DKTatlas lh volume lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0834995	0.1208532	0.4971846
Weighted median	23	-0.0124417	0.0625674	0.8423775
Inverse variance weighted	23	-0.0458397	0.0462661	0.3217904
Simple mode	23	-0.0329484	0.1131725	0.7736760
Weighted mode	23	0.0117829	0.0760266	0.8782470

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.03929	21	0.0730066
Inverse variance weighted	31.20868	22	0.0919238

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023123	0.0068303	0.7383224

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009879	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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