Two sample MR report

Telomere_length against aparc-DKTatlas lh volume lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1134895	0.1532208	0.4670819
Weighted median	23	-0.1266965	0.0623300	0.0420855
Inverse variance weighted	23	-0.0180029	0.0591333	0.7607881
Simple mode	23	-0.0861680	0.1337095	0.5259522
Weighted mode	23	-0.1134223	0.0892511	0.2170656

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.89444	21	0.0003773
Inverse variance weighted	50.98348	22	0.0004311

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058629	0.0086597	0.5057778

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015514	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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