Two sample MR report

Telomere_length against aparc-DKTatlas lh volume isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1045482	0.1163678	0.3791430
Weighted median	23	0.0548105	0.0557828	0.3258186
Inverse variance weighted	23	0.0168568	0.0457666	0.7126340
Simple mode	23	-0.0079511	0.0929192	0.9325819
Weighted mode	23	0.0452412	0.0602769	0.4608727

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.77798	21	0.1194346
Inverse variance weighted	30.53839	22	0.1059551

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074542	0.0065768	0.2698175

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000931	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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