Two sample MR report

Telomere_length against aparc-DKTatlas lh volume inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1922512	0.1331050	0.1633940
Weighted median	23	-0.0478403	0.0619911	0.4402751
Inverse variance weighted	23	-0.0906209	0.0516455	0.0793153
Simple mode	23	-0.0371531	0.1269045	0.7724458
Weighted mode	23	-0.0240500	0.0972379	0.8069456

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.65756	21	0.0141315
Inverse variance weighted	38.89140	22	0.0145216

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062403	0.007523	0.4161543

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013431	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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