Two sample MR report

Telomere_length against aparc-DKTatlas lh volume inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1985697	0.1143964	0.0972501
Weighted median	23	-0.0123346	0.0579658	0.8314897
Inverse variance weighted	23	0.0246438	0.0481215	0.6085698
Simple mode	23	-0.0332498	0.1155357	0.7762023
Weighted mode	23	-0.0401846	0.0584633	0.4990470

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.81091	21	0.1455961
Inverse variance weighted	33.76172	22	0.0519325

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0137052	0.0064654	0.046107

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010352	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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