Two sample MR report

Telomere_length against aparc-DKTatlas lh volume fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0207802	0.0994061	0.8364289
Weighted median	23	-0.0466696	0.0557458	0.4024881
Inverse variance weighted	23	-0.0499683	0.0388454	0.1983255
Simple mode	23	-0.0528207	0.0957327	0.5866797
Weighted mode	23	-0.0314792	0.0705695	0.6599033

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.93304	21	0.4630400
Inverse variance weighted	21.53086	22	0.4881699

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043439	0.0056181	0.4480258

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007026	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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