Two sample MR report

Telomere_length against aparc-DKTatlas lh volume entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0064723	0.1280284	0.9601592
Weighted median	23	-0.0374586	0.0556796	0.5011047
Inverse variance weighted	23	-0.0444183	0.0490006	0.3646794
Simple mode	23	-0.1040129	0.0962310	0.2914630
Weighted mode	23	-0.0393516	0.0595624	0.5156776

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.83363	21	0.0294448
Inverse variance weighted	35.00561	22	0.0386928

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023299	0.0072359	0.7506432

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011004	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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