Two sample MR report

Telomere_length against aparc-DKTatlas lh volume cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1671915	0.1404572	0.2471966
Weighted median	23	-0.0462122	0.0603723	0.4440013
Inverse variance weighted	23	-0.0268129	0.0551101	0.6265888
Simple mode	23	-0.1316763	0.1065588	0.2295974
Weighted mode	23	0.0442950	0.0831914	0.5997537

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.92727	21	0.0042972
Inverse variance weighted	44.28100	22	0.0032705

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086192	0.0079383	0.2898858

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013561	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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