Two sample MR report

Telomere_length against aparc-DKTatlas lh volume caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1475177	0.1016202	0.1613739
Weighted median	23	-0.1012623	0.0542113	0.0617732
Inverse variance weighted	23	-0.1164485	0.0388992	0.0027571
Simple mode	23	-0.1140255	0.0951546	0.2435430
Weighted mode	23	-0.1013813	0.0627435	0.1203874

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.94604	21	0.4026254
Inverse variance weighted	22.06133	22	0.4562332

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019076	0.0057433	0.7430696

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009408	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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