Two sample MR report

Telomere_length against aparc-DKTatlas lh volume caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0172088	0.0994063	0.8642182
Weighted median	23	-0.0893247	0.0575613	0.1207051
Inverse variance weighted	23	-0.0839546	0.0388454	0.0306761
Simple mode	23	-0.0331765	0.0924836	0.7232182
Weighted mode	23	-0.0870267	0.0700109	0.2269363

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.76177	21	0.5363930
Inverse variance weighted	20.29386	22	0.5646641

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040982	0.0056182	0.4737871

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007565	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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