Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1330238	0.1195561	0.2784351
Weighted median	23	-0.0444689	0.0541113	0.4111884
Inverse variance weighted	23	-0.0409148	0.0464005	0.3778985
Simple mode	23	-0.0424274	0.0809934	0.6056291
Weighted mode	23	-0.0387477	0.0581787	0.5123281

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.37652	21	0.0846790
Inverse variance weighted	31.38983	22	0.0884102

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056554	0.0067569	0.4120301

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009847	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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