Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2159610	0.0994054	0.0414103
Weighted median	23	-0.1067441	0.0569835	0.0610345
Inverse variance weighted	23	-0.0760112	0.0388453	0.0503749
Simple mode	23	0.0860832	0.1109607	0.4461279
Weighted mode	23	-0.0927684	0.0617504	0.1472352

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.55074	21	0.5498555
Inverse variance weighted	21.89006	22	0.4664670

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085929	0.0056182	0.1410689

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007794	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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