Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1678274	0.1147116	0.1582641
Weighted median	23	-0.0475568	0.0590639	0.4207182
Inverse variance weighted	23	-0.0507304	0.0450600	0.2602337
Simple mode	23	0.0124089	0.0990012	0.9013923
Weighted mode	23	0.0057422	0.0768098	0.9410827

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.96564	21	0.1411285
Inverse variance weighted	29.60339	22	0.1284268

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071898	0.0064832	0.2799803

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009487	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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