Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2466665	0.1180582	0.0490288
Weighted median	23	-0.0366118	0.0613129	0.5504204
Inverse variance weighted	23	-0.0905202	0.0472380	0.0553322
Simple mode	23	0.0015508	0.1089555	0.9887721
Weighted mode	23	-0.0244665	0.0940122	0.7970929

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.62288	21	0.0998322
Inverse variance weighted	32.53525	22	0.0687175

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095876	0.0066725	0.1654861

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011503	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8