Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1843590	0.1273303	0.1624165
Weighted median	23	-0.0037330	0.0617062	0.9517608
Inverse variance weighted	23	-0.0375403	0.0503976	0.4563429
Simple mode	23	0.0224033	0.1026656	0.8292720
Weighted mode	23	0.0295833	0.0882170	0.7405398

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.45759	21	0.0323533
Inverse variance weighted	37.03232	22	0.0234634

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090147	0.0071965	0.2240998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011504	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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