Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1247311	0.1001714	0.2267828
Weighted median	23	-0.0158087	0.0557266	0.7766527
Inverse variance weighted	23	-0.0319222	0.0391563	0.4149282
Simple mode	23	0.0009446	0.0975624	0.9923625
Weighted mode	23	-0.0166127	0.0718859	0.8193748

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.32503	21	0.4392542
Inverse variance weighted	22.35382	22	0.4389471

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056985	0.0056615	0.3256164

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006978	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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