Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0419082	0.1104060	0.7080663
Weighted median	23	-0.0238869	0.0614171	0.6973291
Inverse variance weighted	23	0.0099811	0.0424126	0.8139501
Simple mode	23	0.0048648	0.1021442	0.9624433
Weighted mode	23	-0.0147445	0.0840154	0.8622938

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.90485	21	0.2101004
Inverse variance weighted	26.22644	22	0.2420871

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003186	0.0062399	0.6149674

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007967	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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